HDX-MS Protein
Structural Analysis
HDX-MS analysis: It can be used to obtain information on your protein structure, its interaction sites (e.g., protein-protein or protein-ligand), Epitope mapping, allosteric effects, intrinsic disorder, and conformational changes induced by post-translational modifications (PTMs).
HDX-MS has the unique advantage of not being limited by the size of proteins or protein complexes. This technique is highly sensitive, and can able to detect co-existing protein conformations.
- We
provide services for Protein Structural Analysis using
Hydrogen-Deuterium
exchange (HDX) mass spectrometry (MS).
- HDX-MS
has become a popular and
key technique for monitoring structural and dynamic aspects of proteins in
solution.
- This
approach relies on the fact that exposure of a protein to D(2)O induces rapid
amide H → D exchange in disordered regions that lack stable hydrogen-bonding.
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